| Bioactivity | Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis. |
| CAS | 75483-04-4 |
| Formula | C13H12ClNO3 |
| Molar Mass | 265.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hur W, et al., A small-molecule inducer of the antioxidant response element. Chem Biol. 2010 May 28;17(5):537-47. |
Nrf2 activator-10
CAS: 75483-04-4 F: C13H12ClNO3 W: 265.69
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) a
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