| Bioactivity | PFI-6 is a non-cytotoxic and selective MLLT1/3 probe targeting the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). PFI-6 shows IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 can serve as a molecular tool to explore the role of MLLT1/3 in various diseases and related genome validation studies[1]. |
| Target | IC50: 140 nM (MLLT1); 160 nM (MLLT3). |
| Name | PFI-6 |
| CAS | 2675452-91-0 |
| Formula | C22H21N3O4 |
| Molar Mass | 391.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Raux B, et al. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg Med Chem Lett. 2023 Nov 7:129546. |