| Bioactivity | NLRP3-IN-24 (Compounds 15a) is an inhibitor against NLRP3. NLRP3-IN-24 has an inhibitory effect on the activation of NLRP3 inflammasome[1]. |
| Invitro | NLRP3-IN-24 (0.1-10 μM, 1 h) 在 THP-1 细胞和 J774A.1 细胞中可抑制血红素诱导的 NLRP3 介导的炎症反应[1]。NLRP3-IN-24 (10 μM, 24 h) 对 J774.A1 细胞无毒[1]。 0 --> NLRP3-IN-24 相关抗体: Cell Viability Assay [1] Cell Line: |
| In Vivo | NLRP3-IN-24 (10-30mg/kg, Intraperitoneal injection, 30 min before the administration of LPS, single dose) 抑制腹膜炎症模型中 NLRP3 炎症小体的激活[1]。 Animal Model: |
| Name | NLRP3-IN-24 |
| Formula | C19H26O3Si |
| Molar Mass | 330.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shete S S, et al. Sila-CBD Derivatives as Inhibitors of Heme-Induced NLRP3 Inflammasome: Application in Hemolytic Diseases[J]. ACS Medicinal Chemistry Letters, 2023. |