PF-739_product_DataBase

Bioactivity	PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2].
Invitro	PF-739 激活 α2β1γ1、α2β2γ1、α1β1γ1 和 α1β2γ1，EC50 值分别为 5.23 nM、42.2 nM、8.99 nM 和 126 nM[1]。PF-739 (0-1000 nM) 以剂量依赖性方式增加原代大鼠肝细胞和原代人心肌细胞系的肌管中 AMPK 底物磷酸化[2]。
In Vivo	PF-739 (30-1000 mg/kg；口服或皮下注射；单剂量) 有效激活 C57BL/6 小鼠肝细胞和骨骼肌中的 AMPK，降低血浆葡萄糖水平[2]。 Animal Model:
Name	PF-739
CAS	1852452-14-2
Formula	C23H23ClN2O5
Molar Mass	442.89
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Aledavood E, et al. Elucidating the Activation Mechanism of AMPK by Direct Pan-Activator PF-739[J]. Frontiers in Molecular Biosciences, 2021, 8: 760026. [2]. Cokorinos EC, et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab. 2017 May 2;25(5):1147-1159.e10.

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