| Bioactivity | PF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 hydrochloride inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 hydrochloride also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM[1]. |
| In Vivo | PF-6870961 hydrochloride (40 mg/kg；腹腔注射) 抑制饱食和禁食大鼠的食物摄入[1]。 Animal Model: |
| Name | PF-6870961 hydrochloride |
| CAS | 2857112-07-1 |
| Formula | C29H33ClN6O2S |
| Molar Mass | 565.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Deschaine SL, et al. Initial pharmacological characterization of a major hydroxy metabolite of PF-5190457: inverse agonist activity of PF-6870961 at the ghrelin receptor. J Pharmacol Exp Ther. 2023 Jan 11:JPET-AR-2022-001393. |
PF-6870961 hydrochloride
CAS: 2857112-07-1 F: C29H33ClN6O2S W: 565.13
PF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and
Data collection：peptidedb@qq.com
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