| Bioactivity | PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse[1]. | ||||||||||||
| Target | IC50: 97 nM (rTrpA1), 23 nM (hTrpA1) | ||||||||||||
| In Vivo | PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse[1]. Animal Model: | ||||||||||||
| Name | PF-4840154 | ||||||||||||
| CAS | 1332708-14-1 | ||||||||||||
| Formula | C26H38N6O2 | ||||||||||||
| Molar Mass | 466.62 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Ryckmans T, et al. Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-4859. |
PF-4840154
CAS: 1332708-14-1 F: C26H38N6O2 W: 466.62
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. P
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