| Bioactivity | PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. |
| Invitro | PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM[1]. |
| Name | PF-06737007 |
| CAS | 1863905-38-7 |
| Formula | C25H28F4N2O6 |
| Molar Mass | 528.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. |
PF-06737007
CAS: 1863905-38-7 F: C25H28F4N2O6 W: 528.49
PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and
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