| Bioactivity | PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. |
| Invitro | PF-06733804 (Compound 19) also inhibits hERG in the FP and PX assay with IC50s of 79 μM and 88 μM, respectively[1]. |
| Name | PF-06733804 |
| CAS | 1873373-33-1 |
| Formula | C20H19F5N4O4 |
| Molar Mass | 474.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. |
PF-06733804
CAS: 1873373-33-1 F: C20H19F5N4O4 W: 474.38
PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB an
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