| Bioactivity | PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research[1]. | ||||||||||||
| Name | PF-06454589 | ||||||||||||
| CAS | 1527473-30-8 | ||||||||||||
| Formula | C14H16N6O | ||||||||||||
| Molar Mass | 284.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Ja |
PF-06454589
CAS: 1527473-30-8 F: C14H16N6O W: 284.32
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.