| Bioactivity | L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders research[1]. | |||||||||
| Invitro | In adult rat hippocampal slices, L-826266 (1 μM) prevents the PGE2-induced decrease of Na+,K+-ATPase activity[2]. | |||||||||
| In Vivo | L-826266 (0.01-1 nmol/site; i.c.v.; once) delays seizures, and increases the latency for clonic and generalized tonic-clonic seizures induced by PTZ[1]. Animal Model: | |||||||||
| Name | L-826266 | |||||||||
| CAS | 244101-03-9 | |||||||||
| Formula | C27H21BrClNO4S | |||||||||
| Molar Mass | 570.88 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. M S Oliveira, et al. Modulation of pentylenetetrazol-induced seizures by prostaglandin E2 receptors. Neuroscience. 2008 Apr 9;152(4):1110-8. [2]. Mauro Schneider Oliveira, et al. Prostaglandin E2 modulates Na+,K+-ATPase activity in rat hippocampus: implications for neurological diseases. J Neurochem. 2009 Apr;109(2):416-26. |
L-826266
CAS: 244101-03-9 F: C27H21BrClNO4S W: 570.88
L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders research.
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