| Bioactivity | PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC50 of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable[1]. |
| CAS | 1354712-92-7 |
| Formula | C18H30N4O4 |
| Molar Mass | 366.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Davoren JE, et al., Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4941-4944. |
PF-05020182
CAS: 1354712-92-7 F: C18H30N4O4 W: 366.46
PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC50 of
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