| Bioactivity | ALKBH5-IN-4 (compound 3) is a RNA m6A demethylase ALKBH5 inhibitor with an IC50 of 0.84 μM. ALKBH5-IN-4 shows inhibitory effect on leukemia cells[1]. |
| Invitro | ALKBH5-IN-4 (1-100 μM, 0-48 h) 抑制 HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 细胞增殖的 IC50 分别为 >50, 1.38, 11.9, 47.8, 16.5, >50 μM [1]。ALKBH5-IN-4 (1-100 μM, 2 h) 抑制 RNA m6A 脱甲基酶 ALKBH5 的 IC50 为 0.84 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ALKBH5-IN-4 相关抗体: Cell Viability Assay Cell Line: |
| CAS | 37510-29-5 |
| Formula | C10H10O4S |
| Molar Mass | 226.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Abd El-Haleem AH, et al. Furan- and Furopyrimidine-Based Derivatives: Synthesis, VEGFR-2 Inhibition, and In Vitro Cytotoxicity. ACS Med Chem Lett. 2024 Nov 25;15(12):2150-2157. |