PF-04822163

CAS: 1798334-07-2 F: C19H17ClN2O2 W: 340.80

PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2

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Bioactivity	PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2.4 nM, and 7 nM for PDE1A, PDE1B, and PDE1C respectively. PF-04822163 can be used in the research of attention deficit hyperactivity disorder or Parkinson's disease[1].
In Vivo	PF-04822163 (10 mg/kg; 口服; 单剂量) 在 0.5 h 时大鼠血浆中的 Tmax 为 274 ng/mL，终末半衰期为 5.5 h，且具有血脑屏障透过性[1]。在大鼠药代动力学分析[1]species
CAS	1798334-07-2
Formula	C19H17ClN2O2
Molar Mass	340.80
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Humphrey J M, et al. Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1[J]. MedChemComm, 2014, 5(9): 1290-1296.