| Bioactivity | PF-02575799 is a microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77±0.29 nM. |
| Target | IC50: 0.77±0.29 nM (MTP) |
| Invitro | PF-02575799 is compound 13 from the reference[1]. |
| In Vivo | PF-02575799 produces appreciable triglyceride effects at its minimally effective dose (10 mg/kg). PF-02575799 significant increase alanine transaminase at 100 mg/kg[1]. |
| Name | PF-02575799 |
| CAS | 863491-70-7 |
| Formula | C42H37FN4O4 |
| Molar Mass | 680.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Robinson RP, et al. Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4150-4. |