| Bioactivity | PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1]. |
| Target | IC50: 2.5 nM (PERK) |
| Invitro | 在 A549 细胞中，PERK-IN-6 (Compound 5) 抑制 thapsigargin 诱导的 PERK 自磷酸化，IC50 为 0.1-0.3 μΜ[1]。 |
| In Vivo | SD 大鼠静脉注射 PERK-IN-6 (Compound 5) 后血液清除率为 10.5 mL/min/kg [1]。 |
| Name | PERK-IN-6 |
| CAS | 1337532-14-5 |
| Formula | C23H22N6O |
| Molar Mass | 398.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Axten JM, et al. Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. ACS Med Chem Lett. 2013 Aug 12;4(10):964-8. |