| Bioactivity | PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states[1]. | ||||||||||||
| Target | IC50: 0.3 nM (PERK) | ||||||||||||
| Name | PERK-IN-4 | ||||||||||||
| CAS | 1337531-89-1 | ||||||||||||
| Formula | C24H19F4N5O | ||||||||||||
| Molar Mass | 469.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Axten JM, et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulu |
PERK-IN-4
CAS: 1337531-89-1 F: C24H19F4N5O W: 469.43
PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC
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