| Bioactivity | Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2]. |
| Invitro | Alloxan hydrate inhibits the peptidase activities of the purified 26S and 20S proteasomes[1]. |
| Name | Alloxan hydrate |
| CAS | 2244-11-3 |
| Formula | C4H4N2O5 |
| Molar Mass | 160.08 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Zhou W, et al. Diabetogenic agent alloxan is a proteasome inhibitor. Biochem Biophys Res Commun. 2017;488(2):400-406. [2]. Munday R, et al. The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol. 1993;139(1):153-163. |
Alloxan hydrate
CAS: 2244-11-3 F: C4H4N2O5 W: 160.08
Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrateis a proteasome inhibitor. Alloxan causes dia
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