| Bioactivity | PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1]. |
| Name | PEG6-(CH2CO2H)2 |
| CAS | 77855-76-6 |
| Formula | C14H26O10 |
| Molar Mass | 354.35 |
| Appearance | Oil |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. |
PEG6-(CH2CO2H)2
CAS: 77855-76-6 F: C14H26O10 W: 354.35
PEG6-(CH2CO2H)2 is asymmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dime
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