| Bioactivity | PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC50 of 8.7 nM[1]. |
| Invitro | PDE9-IN-1 is excellent selectivity across PDE families[1]. |
| In Vivo | PDE9-IN-1 (2.5 and 5.0 mg/kg; Oral administration; daily for 21 days) effectively recovers learning and memory function[1]. Animal Model: |
| Name | PDE9-IN-1 |
| CAS | 2305087-92-5 |
| Formula | C17H23FN6O2 |
| Molar Mass | 362.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu Y, et al. Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. J Med Chem. 2019 Apr 25;62(8):4218-4224. |
PDE9-IN-1
CAS: 2305087-92-5 F: C17H23FN6O2 W: 362.40
PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC50 of 8.7 nM.
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