PDE4-IN-11_product_DataBase

Bioactivity	PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research[1][2][3].
Invitro	PDE4-IN-11 (example 12) exerts function in the monocrotaline reversal model of pulmonary hypertension[2].PDE4-IN-11 (compound A1) displays antiinflammatory, anti-airways hyperreactivity and bronch odilator properties. PDE4-IN-11 also possesses immunosuppressive and TNFα secretion inhibitory activities[3].
Name	PDE4-IN-11
CAS	524734-30-3
Formula	C21H19FN2O2
Molar Mass	350.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Denholm A, et al. Preparation of naphthyridines as phosphodiesterase isoenzyme 4 (PDE4) inhibitors: World Intellectual Property Organization, WO2003039544[P]. 2003-05-15. [2]. McCarthy C, et al. Use of naphthyridine derivatives as medicaments for the treatment of pulmonary hypertension: World Intellectual Property Organization, WO2007088019[P]. 2007-08-09. [3]. Press NJ, et al. Organic compounds for treating pulmonary hypertension: World Intellectual Property Organization, WO2009013286. 2009-01-29.

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