PDE1-IN-6_product_DataBase

Bioactivity	PDE1-IN-6 (compound 6c) is a selectivity PDE1 inhibitor with the IC50 of 7.5 nM. PDE1-IN-6 significantly inhibits the proliferation and induced cell apoptosis in Acute myelogenous leukemia cells[1].
Invitro	PDE1-IN-6 (compound 6c) (10 and 20 μM, 48 h) 诱导 U937 和 ML-1 细胞凋亡[1]。PDE1-IN-6 (10 and 20 μM, 48 h) 降低 U937 和 ML-1 细胞中 caspase- 3,7,9、PARP、Bcl-2 和 Bcl-xl 蛋白的表达，增加其切割的 caspase- 3,7,9 的表达量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PDE1-IN-6 相关抗体: Apoptosis Analysis[1] Cell Line:
CAS	2877017-16-6
Formula	C24H26F2N6O
Molar Mass	452.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Le ML, et al. Discovery of novel selective phosphodiesterase‑1 inhibitors for the treatment of acute myelogenous leukemia. Bioorg Chem. 2024;144:107114.

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