| Bioactivity | PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC[1]. | ||||||||||||
| Invitro | PD168393 inhibits ligand-dependent receptor phosphorylation and inhibits EGF-induced tyrosine phosphorylation in A431 cells and Heregulin-induced tyrosine phosphorylation in MDA-MB-453 cells with IC50 values of 4.3 nM and 5.7 nM, respectively[1]. | ||||||||||||
| Name | PD168393 | ||||||||||||
| CAS | 194423-15-9 | ||||||||||||
| Formula | C17H13BrN4O | ||||||||||||
| Molar Mass | 369.22 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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PD168393
CAS: 194423-15-9 F: C17H13BrN4O W: 369.22
PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely
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