| Bioactivity | AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity[1][2]. | ||||||||||||
| Invitro | AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation[1]. AG1024 (1-5 μM; 1-3 days) induces UT7-9 and Baf3-p210 cells apoptosis[1]. AG1024 (2 μM; 6, 12 hours) downregulates phospho-Akt, Bcr-Abl and upregulates DNA-PKcs[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | AG1024 | ||||||||||||
| CAS | 65678-07-1 | ||||||||||||
| Formula | C14H13BrN2O | ||||||||||||
| Molar Mass | 305.17 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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AG1024
CAS: 65678-07-1 F: C14H13BrN2O W: 305.17
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 in
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