| Bioactivity | PD 121373 is a DNA complexing agent with antitumor activity. PD 121373 can bind tightly to DNA and RNA and inhibit the synthesis of DNA and RNA. The IC50 values ??of PD 121373 for inhibiting DNA and RNA synthesis in L1210 cells are 0.5 μM and 0.3 μM, respectively[1]. |
| CAS | 113457-06-0 |
| Formula | C21H27N5OS |
| Molar Mass | 397.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. DAVID W, et al. "Biochemical pharmacology and DNA-drug interactions by Cl-958, a new antitumor intercalator derived from a series of substituted 2H-[1] benzothiopyrano [4, 3, 2-cd] indazoles." Molecular pharmacology 33.1 (1988): 84-92. |
PD 121373
CAS: 113457-06-0 F: C21H27N5OS W: 397.54
PD 121373 is a DNA complexing agent with antitumor activity. PD 121373 can bind tightly to DNA and RNA and inhibit the s
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