PD-1/PD-L1 antagonist 1_product_DataBase

Bioactivity	PD-1/PD-L1 antagonist 1 (Compound A5) is an antagonist for programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) interaction, with an IC50 of 23.78 nM[1].
Target	23.78 nM (PD-1/PD-L1 interaction)
Invitro	PD-1/PD-L1 antagonist 1 (0-3 μM) 剂量依赖性地抑制 Jurkat-NFAT-PD-1 细胞和 Hep3B-OS8-hPD-L1 细胞共系统中的 PD-1 和 PD-L1 相互作用，在剂量范围 3.3 μM 以内对 Jurkat 细胞没有表现出明显的细胞毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PD-1/PD-L1 antagonist 1 相关抗体: Cell Cytotoxicity Assay[1] Cell Line:
Formula	C52H48Cl2N6O8
Molar Mass	955.88
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wu X, et al. Design, Synthesis, and Evaluation of 8-(o-Tolyl) quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists[J]. ACS Medicinal Chemistry Letters, 2024.

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