| Bioactivity | PD-1/PD-L1-IN-10 (compound B2) is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy[1]. | ||||||||||||
| Invitro | PD-1/PD-L1-IN-10 (compound B2) significantly promotes interferongamma secretion in a dose-dependent manner in vitro even at the low concentration of 1 nM[1].PD-1/PD-L1-IN-10 (compound B2) does not affect cell viability of LLC cells and lymph node T-cells[1].PD-1/PD-L1-IN-10 (compound B2, 0-100 nM) stabilizes the PD-L1 protein in mouse Lewis lung carcinoma (LLC) cells. In particular, PD-1/PD-L1-IN-10 (compound B2) maintains the PD-L1 stability in a dose-dependent manner at 58 °C. Suggesting that PD-1/PD-L1-IN-10 (compound B2) could enter LLC cells and then directly binds to the PD-L1 protein[1]. | ||||||||||||
| Name | PD-1/PD-L1-IN-10 | ||||||||||||
| CAS | 2487550-41-2 | ||||||||||||
| Formula | C33H31N3O7 | ||||||||||||
| Molar Mass | 581.62 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
PD-1/PD-L1-IN-10
CAS: 2487550-41-2 F: C33H31N3O7 W: 581.62
PD-1/PD-L1-IN-10 (compound B2) is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.