| Bioactivity | (-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity[1][2]. | |||||||||
| Invitro | (-)-Irofulven (2.8 μM; 1 hour) induces p53-dependent cell cycle arrest[1].(-)-Irofulven (0.8 μM, 0.9 μM and 2.8 μM; 1 hour) induces CHK2 activation is related to p53 status in cells[1].(-)-Irofulven inhibits DNA replication and induces chromosome aberrations (breaks and radials)[1]. Cell Cycle Analysis[1] Cell Line: | |||||||||
| Name | (-)-Irofulven | |||||||||
| CAS | 158440-71-2 | |||||||||
| Formula | C15H18O3 | |||||||||
| Molar Mass | 246.30 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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(-)-Irofulven
CAS: 158440-71-2 F: C15H18O3 W: 246.30
(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA,
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