Bioactivity | PCSK9-IN-23 (compound 5C) is a potent PCSK9 inhibitor. PCSK9-IN-23 blocks PCSK9 secretion from HepG2 cells, significantly increases LDL receptor (LDLR) expression[1]. |
Name | PCSK9-IN-23 |
CAS | 2115700-96-2 |
Formula | C22H18F6N2O |
Molar Mass | 440.38 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Lisa Giannessi, et al. Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability. Eur J Med Chem. 2023 Dec 20:265:116063. |