PAN endonuclease-IN-2_product_DataBase

Bioactivity	PAN endonuclease-IN-2 (compound T-31) is a PAN endonuclease inhibitor (IC50: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication[1].
Target	IC50: 0.15 μM (PAN endonuclease)
Invitro	PAN endonuclease-IN-2 (compound T-31) 在 MDCK 细胞中，针对流感病毒 A (H1N1/A/WSN/33) 而发挥的体外抗流感 EC50 为 0.96 μM；对其他 PR/8(H1N1)、H3N2、H5N1、H9N2、Flu B 的 EC50 分别为 4.76 μM，1.85μM，5.06μM，0.71μM，2.36μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PAN endonuclease-IN-2 相关抗体:
Formula	C25H21Br2NO7
Molar Mass	607.24
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ruan J, et al. Optimization and biological evaluation of l-DOPA derivatives as potent influenza PAN endonuclease inhibitors with multi-site binding characteristics. Bioorg Chem. 2024 Mar;144:107139.

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