Anticancer agent 198_product_DataBase

Bioactivity	Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential WRN protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells[1].
Invitro	Anticancer agent 198 显著抑制 PC3-WRN 细胞的存活，在 PC3-WRN (OE) 细胞和 PC3 细胞间 IC20 分别为 0.12 μM 和 0.98 μM[1]。Anticancer agent 198 (5 μM) 对几种癌细胞系的 IC50s 分别为 >10 μM (PC3 细胞)，0.05 μM (K562 细胞)，1.1 μM (293T 细胞)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 198 相关抗体: Cell Viability Assay[1] Cell Line:
Formula	C25H23F2N3O3
Molar Mass	451.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang M, et al. Design, synthesis and antitumor activity of 2-substituted quinazoline-4-amine derivatives. Bioorg Med Chem. 2024 Mar 15;102:117660.

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