PACAP (1-38) free acid_product_DataBase

Bioactivity	PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1[1][2].
Invitro	PACAP (1-38) free acid (1 nM) 增加 P 物质、胃泌素释放肽和血管活性肠肽的释放[1]。ACAP (1-38) free acid (100 nM; 10 min) 诱导大鼠海马切片中 NR2B 的酪氨酸磷酸化[2]。 Western Blot Analysis[2] Cell Line:
Name	PACAP (1-38) free acid
CAS	129405-61-4
Sequence	His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys
Shortening	HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK
Formula	C203H330N62O54S
Molar Mass	4535.24
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tornøe K, et al. PACAP 1-38 as neurotransmitter in the porcine antrum. Regul Pept. 2001 Sep 15;101(1-3):109-21. [2]. Yaka R, et al. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem. 2003 Mar 14;278(11):9630-8.

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