| Bioactivity | PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model[1]. |
| Invitro | PAA4 (0-4 µM; 24 h) shows no significant cytotoxicity in EJ, HUVEC, SV-HUC-1 cell lines with IC50 values of 2.1, 0.80, 2.3 µM, respectively[1].PAA4 (4 µM; 1, 3, 6 h) causes significant DNA damage as indicated by the increase of histone H2AX phosphorylation (pH2AX)[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | PAA4 (1.5 µM, 100 µL; intravesical delivered into the bladder; 5 times every other day for 8 days) shows anti-tumor activity in mouse[1]. Animal Model: |
| Name | PAA4 |
| Formula | C14H8Au4BF4N |
| Molar Mass | 1064.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiao K, et al. Pro-oxidant response and accelerated ferroptosis caused by synergetic Au(I) release in hypercarbon-centered gold(I) cluster prodrugs. Nat Commun. 2022 Aug 9;13(1):4669. |