| Bioactivity | P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC50s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC50 of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models[1]. |
| Sequence | Val-Asp-Leu-Gly-Asp-Ile-Ser-Gly-Ile-Asn-Ala-Ser-Val-Val-Asn-Ile-Gln-Lys-Glu-Ile-Asp-Arg-Leu-Asn-Glu-Val-Ala-Lys-Asn-Leu-Asn-Glu-Ser-Leu-Ile-Asp-Leu-Gln-Glu-Leu-Gly-Ser-Gly-Ser-Gly-Cys-PEG4-(CH2CO2)-Cholesterol |
| Shortening | VDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGSGSGC-PEG4-(CH2CO2)-Cholesterol |
| Formula | C241H407N59O80S |
| Molar Mass | 5443.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu L, et al., A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery. Sci China Life Sci. 2023 Oct;66(10):2201-2213. |