| Bioactivity | P-gp inhibitor 13 is a P-gp inhibitor. P-gp inhibitor 13 can reverse P-glycoprotein-mediated paclitaxel resistance in A2780/T cell. P-gp inhibitor 13 can be used for the research of advanced acute myeloid leukemia[1]. |
| Invitro | P-gp inhibitor 13 (Compound 27f) 在 A2780/T 细胞中表现出显着的化学敏感性，IC50 值为 0.010 μM[1]。P-gp inhibitor 13 通过抑制 P-gp 有效增加紫杉醇和罗丹明123的积累，逆转多药耐药[1]。P-gp inhibitor 13 几乎没有相关的心脏毒性[1]。P-gp inhibitor 13（2.5 μM、5 μM、10 μM、20 μM）在 A2780/T 细胞中表现出浓度依赖性 MDR 逆转活性[1]。 |
| Name | P-gp inhibitor 13 |
| Formula | C32H34O8 |
| Molar Mass | 546.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang W, et al. Design, synthesis and biological evaluation of seco-DSP/DCK derivatives reversing P-glycoprotein-mediated paclitaxel resistance in A2780/T cells. Eur J Med Chem. 2023;250:115218. |