| Bioactivity | Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation[1][2][3]. | ||||||
| Invitro | OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. | ||||||
| Name | Orexin B, rat, mouse TFA | ||||||
| Shortening | RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2 | ||||||
| Formula | C₁₂₈H₂₁₆F₃N₄₅O₃₆S | ||||||
| Molar Mass | 3050.42 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Orexin B, rat, mouse TFA
CAS: F: C₁₂₈H₂₁₆F₃N₄₅O₃₆S W: 3050.42
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and act
Data collection：peptidedb@qq.com
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