Opipramol dihydrochloride_product_DataBase

Bioactivity	Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD)[1][2].
Invitro	Opipramol 可抑制粗突触体制剂中 [3H] DA 的吸收，其 IC50 值为 5.5 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Opipramol dihydrochloride 相关抗体:
In Vivo	Opipramol (i.p.; 5-50 mg/kg) 可增加体内多巴胺释放[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	909-39-7
Formula	C23H31Cl2N3O
Molar Mass	436.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Möller HJ, et al. Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group. J Clin Psychopharmacol. 2001 Feb;21(1):59-65. [2]. Rao TS, et al. Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo. Neuropharmacology. 1990 Dec;29(12):1191-7.

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