| Bioactivity | OTS964 is an orally active, high affinity and selective TOPK inhibitor with an IC50 of 28 nM[1]. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2]. |
| Invitro | OTS964 (10 nM; 48 hours) suppresses cancer cell proliferation[1]. OTS964 (10 nM; 48 hours) increases cancer cell death[1]. OTS964 (0.1-2 μM; 24 and 48 hours) increases the expression of LC3-II and decreases the expression of P62, both in a dose-dependent manner[3]. Cell Proliferation Assay[1] Cell Line: |
| Name | OTS964 |
| CAS | 1338542-14-5 |
| Formula | C23H24N2O2S |
| Molar Mass | 392.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
OTS964
CAS: 1338542-14-5 F: C23H24N2O2S W: 392.51
OTS964 is an orally active, high affinity and selective TOPK inhibitor with an IC50 of 28 nM. OTS964 is also a potent in
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