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ODN 105870

Bioactivity ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research[1].
Invitro ODN 105870 potently inhibits the TLR7-induced TNF-α response in bone marrow-derived macrophages (BMDMs)[1].In case of Imiquimod-stimulated B cells, ODN 105870 (10 μM) reduces the ATP content to the pretreatment level[1].
Name ODN 105870
CAS 1965342-40-8
Sequence DNA, d(P-thio)(T-C-C-T-G-G-C-c7G-G-G-G-A-A-G-T)
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Franziska Römmler, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53.

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