ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research.
| Bioactivity | ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research[1]. |
| Invitro | ODN 105870 potently inhibits the TLR7-induced TNF-α response in bone marrow-derived macrophages (BMDMs)[1].In case of Imiquimod-stimulated B cells, ODN 105870 (10 μM) reduces the ATP content to the pretreatment level[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Name | ODN 105870 |
| CAS | 1965342-40-8 |
| Sequence | DNA, d(P-thio)(T-C-C-T-G-G-C-c7G-G-G-G-A-A-G-T) |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Franziska Römmler, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53. |
ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research.