| Bioactivity | HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α)[1]. |
| Invitro | HDMAPP triammonium (化合物 3E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性[1]。 |
| In Vivo | HDMAPP triammonium (化合物 3E) (0.02-2.5 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞[1]。 Animal Model: |
| Name | HDMAPP triammonium |
| CAS | 443892-56-6 |
| Formula | C5H21N3O8P2 |
| Molar Mass | 313.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51(6):1747-54. |