| Bioactivity | OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin[1]. |
| Target | Stomatin, STOML1, STOML2, STOML3 |
| Invitro | OB-1 (3 h) 减少 N2a 细胞的机械传导电流，IC50 为 10 nM[1]。 |
| In Vivo | OB-1 (250-500 pmol per paw; s.c.; once) 可逆地降低感觉神经元中机械门控电流的敏感性，并使小鼠的机械感受器沉默[1]。OB-1 (250 pmol per paw; s.c.; once) 减轻小鼠疼痛性糖尿病神经病变[1]。 Animal Model: |
| Name | OB-1 |
| CAS | 300803-69-4 |
| Formula | C21H17N3O6 |
| Molar Mass | 407.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wetzel C, et al. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat Neurosci. 2017 Feb;20(2):209-218. |