| Bioactivity | Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist[1]. | ||||||
| Invitro | Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1]. | ||||||
| Name | Neurokinin A(4-10) TFA | ||||||
| Sequence | Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 | ||||||
| Shortening | DSFVGLM-NH2 | ||||||
| Formula | C36H55F3N8O12S | ||||||
| Molar Mass | 880.93 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |