| Bioactivity | Neuraminidase-IN-20 (Compound 5i) is a potent inhibitor of mutant neuraminidase (NA) (H5N1-H274Y) (IC50= 0.44 μM).Neuraminidase-IN-20 binds to the 430 cavity site of NA and disrupts the enzymatic activity of NA[1]. |
| Invitro | Neuraminidase-IN-20 (45-66 μM; 72 h) 在 A549 细胞中显示出一定的细胞毒性[1]。Neuraminidase-IN-20 与 NA 中的若干关键残基形成了多个氢键 (比如 Arg118 和 Arg371)，显著提高了对 NA 的抑制效果[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Neuraminidase-IN-20 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| Formula | C21H18FN3O2S |
| Molar Mass | 395.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fu SK, et al.Discovery andsynthesis of novel benzoylhydrazone neuraminidase inhibitors. Bioorg Med Chem Lett. 2024 Jun 1;105:129743. |