Rusfertide

CAS: 1628323-80-7 F: C114H181N27O28S2 W: 2441.95

Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and tran

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Bioactivity	Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis[1][2].
In Vivo	Rusfertide 限制红细胞 (RBCs) 中的铁毒性 (1 mg/kg，皮下注射，每两天一次，共 49 天) 和转铁蛋白饱和度 (2.5 mg/kg，皮下注射，每两天一次，共 2 周)，提高红细胞的携氧能力，改善 β-地中海贫血和遗传性血色素沉着症小鼠模型中的贫血和铁沉积[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1628323-80-7
Sequence	{Asp(N-(3-methyl-1-oxobutyl))}-Thr-His-Phe-Pro-Cys-Ile-{Lys(γGlu-C16 acid)}-Phe-Glu-Pro-Arg-Ser-Lys-Gly-Cys-Lys-NH2 (disulfide bridge: Cys6-Cys16)
Shortening	{Asp(N-(3-methyl-1-oxobutyl))}-THFPCI-{Lys(γGlu-C16 acid)}-FEPRSKGCK-NH2 (disulfide bridge: Cys6-Cys16)
Formula	C114H181N27O28S2
Molar Mass	2441.95
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Taranath R, et al., Regulation of iron homeostasis by PTG-300 improves disease parameters in mouse models for beta-thalassemia and hereditary hemochromatosis[J]. Blood, 2019, 134: 3540. [2]. Kremyanskaya M, et al., PTG-300 eliminates the need for therapeutic phlebotomy in both low and high-risk polycythemia vera patients[J]. Blood, 2020, 136: 33-35.

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