| Bioactivity | Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.IC50 value: 80 nMTarget: Nav 1.7Nav1.7-IN-2 is useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorder. The more detailed information please refer to WO 2011103196 A1. Nav1.7-IN-2 is a Nav1.7 channel inhibitor extracted from patent WO/2011103196 A1, compound example J, has an IC50 of 80 nM. | ||||||||||||
| Name | Nav1.7-IN-2 | ||||||||||||
| CAS | 1332295-35-8 | ||||||||||||
| Formula | C22H22FN5O2 | ||||||||||||
| Molar Mass | 407.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Bregman Howard, et al. Preparation of aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain. From PCT Int. Appl. (2011), WO 2011103196 A1 20110825. |
Nav1.7-IN-2
CAS: 1332295-35-8 F: C22H22FN5O2 W: 407.44
Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.IC50 value
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