| Bioactivity | LP-471756 is a potent GPR139 antagonist with an IC50 value of 640 nM. LP-471756 inhibits LP-360924-stimulated cAMP production[1][2]. | ||||||||||||
| Target | IC50: 640 nM (GPR139) | ||||||||||||
| Invitro | LP-471756 (0-1000 µM) 特异性抑制 GPR139 细胞中 LP-360924 刺激的 cAMP 的生成，IC50 值为 0.64 µM[2]。 | ||||||||||||
| Name | LP-471756 | ||||||||||||
| CAS | 413605-11-5 | ||||||||||||
| Formula | C19H23NO2S | ||||||||||||
| Molar Mass | 329.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Vedel L, et al. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):35-46. [2]. Hu LA, et al. Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139. J Biomol Screen. 2009 Aug;14(7):789-97. |
LP-471756
CAS: 413605-11-5 F: C19H23NO2S W: 329.46
LP-471756 is a potent GPR139 antagonist with an IC50 value of 640 nM. LP-471756 inhibits LP-360924-stimulated cAMP produ
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