NUCC-0226272_product_DataBase

Bioactivity	NUCC-0226272 is a potent PROTAC that targets EZH2 for degradation. NUCC-0226272 has anti-proliferative effect. NUCC-0226272 has the potential for cancer research[1].
Invitro	NUCC-0226272 (0.01-10 μM；5 天) 对 LNCaP 和 22Rv1 细胞具有抗增殖作用[1]。NUCC-0226272 (10 μM；6 天) 显示 EZH2 的强烈降解，PRC2 成分 SUZ12 的减少，以及 C4-2B 细胞中 H3K27me3 水平的降低[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NUCC-0226272 相关抗体:
In Vivo	Pharmacokinetic Parameters of NUCC-0226272 in C57Bl/6 mouse[1].
CAS	3004503-12-9
Formula	C67H91N9O8S
Molar Mass	1182.56
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gary E. Schiltz, et al. Substituted 3-amino-5-phenylbenzamide compounds as covalent inhibitors of enhancer zeste homolog 2 (ezh2) and proteolysis-targeting chimeric derivatives thereof (protacs) that induce degradation of ezh2. US20230346953A1.

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