| Bioactivity | BAL-0028 (Compound 3) is a NLRP3 activation inhibitor with a IC50 value of 25 nM. BAL-0028 binds closely to the NACHT domain of the NLRP3 with KD values of 104-123 nM. BAL-0028 has anti-inflammatory activity[1]. |
| CAS | 2842012-69-3 |
| Formula | C24H22FN3O2 |
| Molar Mass | 403.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hartman G, et al. The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening. Bioorg Med Chem Lett. 2024 Feb 28;102:129675. |
BAL-0028
CAS: 2842012-69-3 F: C24H22FN3O2 W: 403.45
BAL-0028 (Compound 3) is a NLRP3 activation inhibitor with a IC50 value of 25 nM. BAL-0028 binds closely to the NACHT do
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