| Bioactivity | NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer[1]. |
| Invitro | NSC2805 has WWP2 inhibitory activity with an IC50 of 0.38 μM[1].NSC2805 shows a significant reduction in activity for all three proteins (WWP2, WWP1 and Nedd4)[1].NSC2805 can robustly inhibit WWP2-dependent PTEN ubiquitination[1]. |
| Name | NSC2805 |
| CAS | 4371-34-0 |
| Formula | C14H14O4 |
| Molar Mass | 246.26 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Jessica E Watt, et al. Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors. Chemistry. 2018 Dec 3;24(67):17677-17680. |