NSC260594

CAS: 906718-66-9 F: C29H24N6O3 W: 504.54

NSC260594 induces Apoptosis. NSC260594 binds the shallow groove of the Mcl-1 protein, and inhibits Mcl-1 expression thro

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Bioactivity	NSC260594 induces Apoptosis. NSC260594 binds the shallow groove of the Mcl-1 protein, and inhibits Mcl-1 expression through down-regulation of Wnt signaling proteins. NSC260594 can also recognize G9-G10-A11-G12 RNA tetraloop of HIV and prevent the binding of the Gag protein within the 5’-UTR. NSC260594 inhibits tumor growth, and can be used for research of Triple-negative breast cancers (TNBCs)[1].
Name	NSC260594
CAS	906718-66-9
Formula	C29H24N6O3
Molar Mass	504.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Dong S, et al. Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy. Sci Rep. 2023 Jul 22;13(1):11843.