| Bioactivity | JNK-1-IN-2 (Compound c6) is a JNK-1 inhibitor (IC50: 33.5 nM). JNK-1-IN-2 also inhibits JNK-2 and JNK-3 with IC50s of 112.9 nM and 33.2 nM. JNK-1-IN-2 inhibits the phosphorylation of c-Jun. JNK-1-IN-2 reverses lung impairment. JNK-1-IN-2 can be used for research of pulmonary fibrosis[1]. |
| Target | 33.5 nM, 112.9 nM and 33.2 nM (JNK-1, JNK-2 and JNK-3) |
| Name | JNK-1-IN-2 |
| Formula | C16H20BrN5O |
| Molar Mass | 378.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qian H, et al. Synthesis-accessibility-oriented design of c-Jun N-terminal kinase 1 inhibitor. Eur J Med Chem. 2023 Aug 5;256:115442. |